Context: Non-puerperal uterine inversion is an unusual entity, the majority are caused by benign myomas. Objective: We performed a systematic review to investigate the number of published cases of non-puerperal uterine inversion and to describe one case report. Methods: We searched MEDLINE, EMBASE, LILACS, the Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, the Web of Science, SCOPUS, Conference Abstracts, and grey literature (Google scholar; the British Library) for papers published from January 1940 through October 2016. Patients: women with non-puerperal uterine inversion, Main Outcome: non-puerperal uterine inversion Measurements and main results We found a total of 171 case reports. The most common cause was leyomioma (57.2%) followed by sarcoma (13.5%). The definitive treatment of most cases was hysterectomy (86.8%). Regarding the one case report that we selected, the patient was a 24-year-old woman who had lower abdominal pain, offensive vaginal discharge, and a huge protruding mass per vagina A clinical diagnosis of non-puerperal uterine inversion was made and she successfully underwent an abdominal hysterectomy. Conclusion: Non-puerperal uterine inversion is rare. There have been 171 cases reports in the literature since 1950, and the patient in our case report exhibited a good prognosis during the post-operative period.